CD30,又称KI抗原和Tnfrsf8,是一种120kdaI型跨膜糖蛋白,属于tnf受体超家族。成熟的人CD30由一个361AA细胞外域(ECD)和六个富含半胱氨酸的重复,28AA跨膜段和188AA细胞质域。相比之下,小鼠和大鼠CD30缺乏90AA的ECD,并且只包含三个富含半胱氨酸的重复。在ECD的共同区域内,人CD30与小鼠CD30和大鼠CD30的序列认同率分别为53%和49%。人类CD30的交替剪接产生一个等形,包括细胞质域的C132AA。CD30通常在抗原细胞和B细胞上表达。但是,它在霍奇金氏病(红-斯特恩伯格细胞上)、其他淋巴瘤、慢性炎症中,以及自体免疫。CD30与CD30配体/tnfsf8结合,TH细胞、单核细胞、粒细胞和髓质胸腺上皮细胞上表达。产品性质别名CD30;CD30KI-1;CD30Lreceptor;TNFRSF8;D1S166EKi-1;CD30KI-1工会编号P28908-1表达区间及表达系统重组的人CD30/Tnfrsf8蛋白表达于在C-端有标记和AVI标记的HK293细胞。它含有……。分子量大约41.3公里。由于糖基化,蛋白质迁移到70-100kda基于三联页面结果。纯度SDS-PAGE和高效液相色谱法测定的95%。Kex2不能识别和切割单一碱性氨基酸即精氨酸或赖氨酸的羧基端肽键。Recombinant Human TIE2 Protein,His Tag
SARS-CoV-2, which causes the global pandemic coronavirus disease 2019 (Covid-19), belongs to a family of viruses known as coronaviruses that also include MERS‑CoV and SARS-CoV-1. Coronaviruses are commonly comprised of four structural proteins: Spike protein (S), Envelope protein (E), Membrane protein (M) and Nucleocapsid protein (N). The SARS-CoV-2 S protein is a glycoprotein that mediates membrane fusion and viral entry. The S protein is homotrimeric, with each ~180-kDa monomer consisting of two subunits, S1 and S2 .The RBD of SARS-CoV-2 binds a metallopeptidase, angiotensin-converting enzyme 2 (ACE-2). Before binding to the ACE-2 receptor, structural analysis of the S1 trimer shows that only one of the three RBD domains is in the "up" conformation. This is an unstable and transient state that passes between trimeric subunits but is nevertheless an exposed state to be targeted for neutralizing antibody therapy. Polyclonal antibodies to the RBD of the SARS-CoV-2 protein have been shown to inhibit interaction with the ACE-2 receptor, confirming RBD as an attractive target for vaccinations or antiviral therapy. Recombinant Cynomolgus RGM-C Protein,His TagOSM与白血病抑制因子(LIF)密切相关,实际上,除了其在人类中的特定受体外,它实际上还使用了LIF受体。
Recombinant Biotinylated Human MSLN/Mesothelin Protein,hFc-Avi Tag分子别名(Synonyms)Mesothelin;CAK1;MSLN;MPFSMRP表达区间及表达系统(Source)BiotinylatedHumanMSLN/MesothelinProteinisexpressedfromHEK293withhFctagandAvitagattheC-Terminus.ItcontainsGlu296-Gly580.[Accession|Q13421-2]分子量大小(MolecularWeight)TheproteinhasapredictedMWof61.1kDa.Duetoglycosylation,theproteinmigratesto70-80kDabasedonSDS-PAGEresult.(Endotoxin)Lessthan1EUperμgbytheLALmethod.纯度(Purity)>95%asdeterminedbySDS-PAGEandHPLC.活性(Activity)ELISAData:ImmobilizedAnti-MSLNAntibody,hFcTagat1μg/ml(100μl/well)ontheplate.DoseresponsecurveforBiotinylatedHumanMSLN,hFcTagwiththeEC50of18.4ng/mldeterminedbyELISA.
糖苷内切酶H是一种重组糖苷酶,能够对N-糖蛋白中的高甘露糖和某些杂合型寡聚糖的壳二糖结构进行切割,去除糖蛋白中的N-连接高甘露糖。糖苷内切酶H克隆自褶皱链霉菌(Streptomycesplicatus)。并在酵母中重组表达。本产品带his标签,常应用于抗体及其相关蛋白完全去糖基化。另外,我司还提供其他类型的糖苷酶,包括糖苷内切酶S(Cat#20413ES),酵母重组表达的N-糖苷酶F(比活性:750000U/mL),酵母重组表达的N-糖苷酶F(比活性:100000U/mL)。储存条件-15~-25℃保存,有效期1年。使用说明变性条件下蛋白质去糖基化1)在水中加入1μLBuffer1和目标糖蛋白(1-20μg),至终体积10μL;2)100℃温度下煮沸10min使其变性,冰上冷却,离心10秒;3)加入2μL的Buffer2,8μL去离子水,总反应体积20μL;4)加入1-2μL的EndoH,轻轻混匀。在37℃孵育1-3h。5)65℃下热失活10分钟。非变性条件下蛋白质去糖基化1)在水中加入2μL的Buffer2和目标糖蛋白(1-20μg)至终体积为20μL。2)加入2~5μL的EndoH,轻轻混匀。3)37°C孵育4-24h。注意:在变性条件下大多数底物能够更好的去糖基化,在非变性条件下可能需要增加EndoH的量和延长孵育时间。双碱性内切酶又称为Kex2蛋白酶、YSCF蛋白酶,在酵母体内Kex2蛋白酶负责加工killer toxin和α-factor的前体。
CD30活性艾利莎数据:固定化抗CD30抗体,板上的氢氟碳化合物标记为0.5欧氏/毫升(100欧氏/井)。生物化人CD30的剂量反应曲线,以49ng/ml的EC50作为标记。艾丽莎数据:固定了人的CD30配体,他的标签在板上5g/ml(100ml/井)。用酶联免疫吸附法测定人CD30的剂量反应曲线,标记为27.1ng/ml的EC50。产品用Lal法测定每一种蛋白质。制剂在PBS(PPS)中用0.22离子过滤溶液冻干(PH7.4)。通常在冻干前添加5%海藻糖作为保护剂。复溶离心管打开前。建议重组到超过100克/毫升的浓度(冻干通常使用1毫克/毫升溶液)。在蒸馏水中溶解冻干蛋白。运输与保存方法冰袋运输。-20℃至-80℃保存,一年有效期。复溶后,-20至-80°C,在未开封状态下保存3-6个月。复溶后,2-8°C保存2-7天。建议使用时分装冻存,避免反复冻融。注意事项1.避免反复冻融。2.为了您的安全和健康,请穿实验服并戴一次性手套操作。3.本产品作科研用途!产品数据通过研究,CDNF可防止6-羟基多巴胺(6-OHDA)诱导的多巴胺能神经元变性,这可能对帕金森氏病有益。Recombinant Human TFPI-2 Protein,His Tag
凝血酶是由大小分别为31 KD和6 KD的两条肽链通过二硫键组成的一种丝氨酸蛋白水解酶。Recombinant Human TIE2 Protein,His Tag
SARS-CoV-2,whichcausestheglobalpandemiccoronavirusdisease2019(Covid-19),belongstoafamilyofvirusesknownascoronaviruses.TheSARS-CoV-2Sproteinisaglycoproteinthatmediatesmembranefusionandviralentry.TheRBDofSARS-CoV-2bindsametallopeptidase,angiotensin-convertingenzyme2(ACE-2).SeveralemergingSARS-CoV-2genomeshavebeenidentifiedincludingtheOmicron,orB.1.1.529,variant.FirstidentifiedinNovember2021inSouthAfrica,theOmicronvariantquicklybecamethepredominantSARS-CoV-2variantandisconsideredavariantofconcern(VOC).TheOmicronvariantcontains15mutationsinRBDdomainthatpotentiallyaffectviralfitnessandtransmissibility.ThemajorityofthemutationsareinvolvedinACE-2bindingandOmicronbindsACE-2withgreateraffinity,potentiallyexplainingitsincreasedtransmissibility.Severalofthesemutationsarealsoidentifiedinfacilitatingimmuneescapeandreducingneutralizationactivitytoseveralmonoclonalantibodies.Recombinant Human TIE2 Protein,His Tag
One Step RT-qPCR SYBR Green Kit (UDG Plus):高效、特异且防污染的RNA定量检测解决方案One Step RT-qPCR SYBR Green Kit (UDG Plus) 是一种为RNA模板设计的一步法实时荧光定量PCR(qPCR)试剂盒,结合了SYBR Green I荧光染料和UDG防污染系统,能够在同一反应管中完成逆转录和qPCR反应,操作简便且高效。产品特点高灵敏度与特异性:采用优化的逆转录酶和热启动Taq DNA聚合酶,结合SYBR Green I染料,能够高效检测低丰度RNA模板,同时减少非特异性扩增。UDG防污染系统:含有dUTP和UDG酶...